Researchers Identify Molecule That Shows Promise for Hair Regeneration

miRNA molecule could potentially promote hair regeneration and play a key role in hair follicle growth cycle.

Researchers from North Carolina State University have identified a molecule known as a microRNA (miRNA) that could promote hair regeneration.

This miRNA plays an important role in regulating the pathway involved in follicle regeneration, and could be a candidate for future drug development.

The study was published in the journal Science Advances.

New treatments in the pipeline for hair regrowth

Hair regeneration depends on the health of dermal papillae (DP) cells, which regulate the hair follicle growth cycle.

Current treatments for hair loss can be costly and ineffective, ranging from invasive surgery to chemical treatments that don’t produce the desired result.

Recent hair loss research indicates that hair follicles don’t disappear where balding occurs, they just shrink.

If DP cells could be replenished at those sites, the thinking goes, then the follicles might recover.

Growing dermal papillae cells in the lab

A research team at NC State’s College of Veterinary Medicine cultured these dermal papillae cells both alone (2D) and in a 3D spheroid environment.

A spheroid is a three-dimensional cellular structure that effectively recreates a cell’s natural microenvironment.

In a mouse model of hair regeneration, lead researcher Ke Cheng looked at how quickly hair regrew on mice treated with 2D cultured DP cells, 3D spheroid-cultured DP cells in a keratin scaffolding, and the commercial hair loss treatment Minoxidil.

In a 20-day trial, mice treated with the 3D DP cells had regained 90% of hair coverage at 15 days.

Promoting follicle growth in the lab as a step toward hair regeneration

“The 3D cells in a keratin scaffold performed best, as the spheroid mimics the hair microenvironment and the keratin scaffold acts as an anchor to keep them at the site where they are needed,” Cheng says.

“But we were also interested in how DP cells regulate the follicle growth process, so we looked at the exosomes, specifically, exosomal miRNAs from that microenvironment.”

Exosomes are tiny sacs secreted by cells that play an important role in cell-to-cell communication.

Those sacs contain miRNAs, and MiRNAs are small molecules that regulate gene expression.

Cheng and his team measured miRNAs in exosomes derived from both 3D and 2D DP cells.

In the 3D DP cell-derived exosomes, they pinpointed miR-218-5p, a miRNA that enhances the molecular pathway responsible for promoting hair follicle growth.

They found that increasing miR-218-5p promoted hair follicle growth, while inhibiting it caused the follicles to lose function.

MiRNAs represent an easier approach to reversing baldness

Cell therapy with the 3D cells could be an effective treatment for baldness, but you have to grow, expand, preserve and inject those cells into the area,” Cheng says.

“MiRNAs, on the other hand, can be utilized in small molecule-based drugs. So potentially you could create a cream or lotion that has a similar effect with many fewer problems.

Future studies will focus on using just this miRNA to promote hair growth.”

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